Maurice Ralph Hilleman (August 30, 1919 – April 11, 2005) was a leading American microbiologist who specialized in vaccinology and developed over 40 vaccines, an unparalleled record of productivity. He has been called the "father of modern vaccines". Robert Gallo called Hilleman "the most successful vaccinologist in history". He has been described by some researchers as having saved more lives than any other scientist in the 20th century. During the influenza pandemic in Southern China, his vaccine is believed to have saved hundreds of thousands of lives. He also played a key role in developing the vaccine for the Hong Kong flu, as well as roles in the discovery of antigenic shift and drift, the cold-producing adenoviruses, the hepatitis viruses, and the potentially cancer-causing virus SV40.

Biography

Early life and education

Hilleman was born on a farm near the high plains town of Miles City, Montana. His parents were Anna (Uelsmann) and Gustav Hillemann, and he was their eighth child. His twin sister died on the day the twins were born, and his mother died two days later. He was raised in the nearby household of his uncle, Bob Hilleman, and worked in his youth on the family farm. He credited much of his success to his work with chickens as a boy; since the 1930s, fertile chicken eggs had often been used to grow viruses for vaccines. Due to lack of funds, he almost failed to attend college. His eldest brother interceded, and Hilleman graduated first in his class in 1941 from Montana State University with family help and scholarships. He won a fellowship to the University of Chicago and received his doctoral degree in microbiology in 1944. His doctoral thesis was on chlamydia infections, which were then thought to be caused by a virus. Hilleman showed that these infections were actually caused by a species of bacterium, Chlamydia trachomatis, that grows only inside of cells.

In 1957, Hilleman joined Merck & Co. (Rahway, New Jersey), as head of its new virus and cell biology research department in West Point, Pennsylvania. It was at Merck that Hilleman developed most of the forty experimental and licensed animal and human vaccines for which he is credited, working both at the laboratory bench as well as providing scientific leadership.

Hilleman served on many national and international advisory boards and committees, academic, governmental and private, including the National Institutes of Health's Office of AIDS Research Program Evaluation and the Advisory Committee on Immunization Practices of the National Immunization Program.

Asian flu pandemic

Hilleman was among the first to recognize that a 1957 outbreak of influenza in Hong Kong could become a huge pandemic. Working on a hunch, after nine 14-hour days he and a colleague determined that it was a new strain of flu that could kill millions. Forty million doses of vaccines were prepared and distributed. Although 69,000 Americans died, the pandemic could have resulted in many more deaths in the United States. Hilleman was awarded the Distinguished Service Medal from the American military for his work. His vaccine is believed to have saved hundreds of thousands of lives.

SV40

Hilleman was one of the vaccine pioneers to warn about the possibility that simian viruses might contaminate vaccines. The best-known of these viruses is SV40, a viral contaminant of some of the polio vaccines produced from 1955-1963. This included some produced for both Salk's inactivated virus vaccine and the then relatively new Albert Sabin's oral live attenuated vaccine.

Mumps vaccine

In 1963, his daughter Jeryl Lynn came down with the mumps. He cultivated material from her, and used it as the basis of a mumps vaccine. The Jeryl Lynn strain of the mumps vaccine is still used. The strain is used in the trivalent (measles, mumps and rubella) MMR vaccine that he also developed, the first approved vaccine to incorporate multiple live virus strains. Like many other vaccines and medications of that time period, the vaccine was tested in children with intellectual disabilities who lived in group homes; this was because, given the poor hygiene and cramped quarters of their accommodations, they were at much higher risk of infectious disease.

Hepatitis B vaccine

He and his group invented

Later work and life

In his later life, Hilleman advised the World Health Organization. He retired as senior vice president of the Merck Research Labs in 1984 at its mandatory retirement age of 65. He then directed the newly created Merck Institute for Vaccinology where he worked for the next twenty years until his death in 2005.

At the time of his death in Philadelphia on April 11, 2005, the Institute of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. In 1988, President Ronald Reagan presented him with the National Medal of Science, the nation's highest scientific honor. He received the Prince Mahidol Award from the King of Thailand for the advancement of public health, as well as a special lifetime achievement award from the World Health Organization, the Mary Woodard Lasker Award for Public Service and the Sabin Gold Medal and Lifetime Achievement Awards. In 1975, Hilleman received the Golden Plate Award of the American Academy of Achievement.

Legacy

In March 2005, the University of Pennsylvania School of Medicine's Department of Pediatrics and The Children's Hospital of Philadelphia, in collaboration with The Merck Company Foundation, announced the creation of The Maurice R. Hilleman Chair in Vaccinology.

Robert Gallo, co-discoverer of HIV (the virus that causes AIDS), said in 2005: "If I had to name a person who has done more for the benefit of human health, with less recognition than anyone else, it would be Maurice Hilleman. Maurice should be recognized as the most successful vaccinologist in history."

In 2005, Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, said that Hilleman's contributions were "the best kept secret among the lay public. If you look at the whole field of vaccinology, nobody was more influential."

In 2007, Paul Offit published a biography of Hilleman, entitled Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases.<blockquote>Maurice was perhaps the single most influential public health figure of the twentieth century, if one considers the millions of lives saved and the countless people who were spared suffering because of his work. Over the course of his career, Maurice and his colleagues developed more than forty vaccines. Of the fourteen vaccines currently recommended in the United States, Maurice developed eight.</blockquote>In 2008, Merck named its Maurice R. Hilleman Center for Vaccine Manufacturing, in Durham, North Carolina, in memory of Hilleman.

In 2009, the American Society of Microbiology (ASM) established the Maurice Hilleman/Merck Award in Vaccinology to honor major contributions to pathogenesis, vaccine discovery, vaccine development, and/or control of vaccine-preventable diseases. The annual award was presented from 2008 to 2018. The first laureate was Stanley Plotkin. Subsequent awardees were Samuel L. Katz (2010),  Albert Z. Kapikian (2011), Myron Levine (2012),  Emil Gotschlich and R. Gwin Follis-Chevron (2013), Dan M. Granoff (2014), Peter Palese (2016) and Stephen Whitehead (2018)

In 2016, a documentary film titled Hilleman: A Perilous Quest to Save the World's Children, chronicling Hilleman's life and career, was released by Medical History Pictures, Inc.

In 2016, Montana State University dedicated a series of scholarships in memory of its alumnus Hilleman, called the Hilleman Scholars Program, for incoming students who "commit to work at their education beyond ordinary expectations and help future scholars that come after them". The program has demonstrated success in supporting Montana students from disadvantaged backgrounds, with the first cohort showing a 78% retention rate, higher than comparable students, while fostering diversity with 36% of the 2022 cohort coming from diverse ethnic and racial backgrounds.

References

  • Hilleman&nbsp;– A Perilous Quest to Save the World's Children (a documentary about his life)