Mashpee may refer to:
- Mashpee, Massachusetts, a town in Massachusetts
- Mashpee Commons, an open-air shopping center
- Mashpee High School, in the town of Mashpee
- Mashpee Middle School, in the town of Mashpee
- Mashpee Neck, Massachusetts, a census-designated place (CDP) in the town of Mashpee
- Mashpee Pond, in the town of Mashpee
- Mashpee River, a tidal river in Mashpee
- Mashpee River Reservation, a park in the town of Mashpee
- Mashpee people, a historical sub-group of the Wampanoag
- Mashpee Wampanoag Tribe, a federally-recognized tribe