Manley as a surname may refer to:

  • Abe Manley (1885–1952), American Negro league baseball owner
  • Alexandra, Countess of Frederiksborg (born Alexandra Christina Manley in 1964), former wife of Prince Joachim of Denmark
  • Alvin Manley (born 1971), American boxer and two-time National Golden Gloves Super Heavyweight Champion
  • Alyssa Manley (born 1994), American field hockey player
  • Andrew Manley, American football quarterback
  • Audrey F. Manley (born 1934), American pediatrician, acting Surgeon General of the United States from 1995 to 1997 and President of Spelman College
  • Brian Manley (1929–2014), UK physicist and engineer
  • Charlotte Manley (born 1957), former Royal Navy officer, now Chapter Clerk of St George's Chapel, Windsor
  • David Manley (philosopher), American philosopher
  • David Manley (artist), British artist, educationalist and arts administrator
  • Delarivier Manley (1663 or c.1670–1724), English author, playwright and political pamphleteer
  • Dex Manley, American commercial and video game voice actor
  • Dexter Manley (born 1959), former American football player
  • Don Manley (born 1945), British crossword compiler
  • Dorothy Manley (1927–2021), British sprinter and Olympic silver medalist in the 100 metres
  • Douglas Manley (1922-2013), Jamaican politician
  • Edna Manley (1900–1987), Jamaican sculptor
  • Effa Manley (1897–1981), American Negro league baseball owner and first woman inducted into the Baseball Hall of Fame; wife of Abe Manley
  • Elizabeth Manley (born 1965), Canadian figure skater and Olympic and world silver medalist
  • George Manley (born 1965), American voice artist, novelist and screenplay writer
  • Ger Manley (born 1968), Irish former hurler
  • Gordon Manley (1902–1980), English climatologist
  • Graham Manley (born 1946), British comic artist
  • James Manley (disambiguation)
  • Jessica Manley (born 1985), British actress
  • Jim Manley (disambiguation)
  • Joe Manley (born 1959), American boxer
  • Joey Manley, American web comic publisher
  • John Manley (disambiguation)
  • Joseph Homan Manley (1842–1905), American politician
  • Kerrie Manley (born 1982), English footballer
  • Leon Manley (1926–2010), American football player and coach
  • Luke Manley, American actor
  • Malcolm Manley (born 1949), Scottish footballer
  • Marion Manley (1893–1984), American architect
  • Martin Manley (born 1952), former US Assistant Secretary of Labor, entrepreneur and founder of online bookseller Alibris
  • Michael Manley (1924–1997), fourth Prime Minister of Jamaica
  • Mike Manley (disambiguation)
  • Natalie Manley, elected to the Illinois House of Representatives in 2012
  • Norman Manley (1893–1969), Jamaican lawyer, politician and Chief Minister of Jamaica
  • Peter Manley (born 1962), former professional darts player
  • Peter Manley (politician) (1903–1998), Canadian politician
  • Phillipkeith Manley (born 1990), American football player
  • Rachel Manley, Jamaican writer
  • Ray Manley (1921–2006), American photographer
  • R.O.B. Manley (1888–1978), British beekeeper
  • Rockcliffe St. J. Manley (1925–2011), Canadian polymer chemist
  • Roddy Manley (born 1965), Scottish former football player
  • Scott Manley (born 1972), Scottish YouTube personality, gamer, programmer, astrophysicist and DJ.
  • Seon Manley (1921–2009), American editor
  • Simon Manley (born 1967), British diplomat
  • Stuart Manley (born 1979), Welsh professional golfer
  • Suliana Manley (born 1975), American biophysicist
  • Tadhg Manley (1893–1976), Irish politician
  • Tom Manley (disambiguation)
  • William Manley (1831–1901), Irish recipient of the Victoria Cross and Surgeon-General