MR2 or MR-2 may refer to:

  • Toyota MR2, a sports car
  • MegaRace 2, a 1996 video game
  • Mercury-Redstone 2, an American space mission
  • Monster Rancher 2, a 1999 video game
  • Nimrod MR2, a military aircraft
  • Beijing–Nanning–Hanoi through train