MHC may refer to:

Biology

  • Major histocompatibility complex, a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions
  • Myosin heavy chain, part of the motor protein myosin's quaternary protein structure

Colleges

  • Mars Hill College (now Mars Hill University), a college in Mars Hill, North Carolina, USA
  • Mount Holyoke College, a college in South Hadley, Massachusetts, USA
  • William E. Macaulay Honors College, an honors college within the City University of New York

Health

  • Managed health care
  • Mental health counselor
  • Metropolitan Hospital Center, East Harlem, New York City

Sports

  • Malaysian Hockey Confederation
  • Mediterranean Handball Confederation
  • Mid Hudson Conference
  • Milwaukee Hurling Club

Other

  • Maimonides Heritage Center
  • Massachusetts Historical Commission
  • Mile High City, common nickname for the city of Denver, Colorado, due to its elevation of exactly one mile above sea level
  • Mile high club
  • Mochoʼ language (ISO 639:mhc), a moribund Mayan language spoken in Chiapas, Mexico
  • Mocopulli Airport (IATA: MHC), Dalcahue, Los Lagos, Chile
  • Model of hierarchical complexity
  • Mohawk–Hudson convergence, a meteorological phenomenon
  • Murphy-Hoffman Company
  • Museum of the History of Catalonia
  • A US Navy hull classification symbol: Coastal minehunter (MHC)