M53, M-53, or M.53 may refer to:

Military

  • M53 155mm Self-Propelled Gun, an American-made tracked, self-propelled gun
  • M53, a Hungarian submachine gun developed from the Soviet PPS-43 submachine gun; see PPS submachine gun#Variants
  • Macchi M.53, an Italian military reconnaissance floatplane of 1928
  • Snecma M53, a French afterburning turbofan engine developed for the Dassault Mirage 2000 fighter
  • M53, Yugoslav copy of the MG42 machine gun
  • M53 Yugoslavian army compass

Roads

  • M-53 (Michigan highway), a state highway in Eastern Michigan
  • M53 highway (Russia), a section of the Baikal Highway in Siberia
  • M53 motorway, a motorway in England
  • M53 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa

Other

  • Messier 53, a globular cluster in the constellation Coma Berenices
  • Samsung Galaxy M53 5G, an Android smartphone by Samsung.