A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive immunity), and innate lymphoid cells (ILCs; "innate T cell-like" cells involved in mucosal immunity and homeostasis), of which natural killer cells are an important subtype (which functions in cell-mediated, cytotoxic innate immunity). They are the main type of cell found in lymph, which prompted the name "lymphocyte" (with cyte meaning cell). Lymphocytes make up between 18% and 42% of circulating white blood cells.
Lymphocytes can be identified by their large nucleus.
T cells and B cells
T cells (thymus cells) and B cells (bone marrow- or bursa-derived cells) are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity (relating to antibodies). The function of T cells and B cells is to recognize specific "non-self" antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored maximally to eliminate specific pathogens or pathogen-infected cells. B cells respond to pathogens by producing large quantities of antibodies which then neutralize foreign objects like bacteria and viruses. In response to pathogens some T cells, called T helper cells, produce cytokines that direct the immune response, while other T cells, called cytotoxic T cells, produce toxic granules that contain powerful enzymes which induce the death of pathogen-infected cells. Following activation, B cells and T cells leave a lasting legacy of the antigens they have encountered, in the form of memory cells. Throughout the lifetime of an animal, these memory cells will "remember" each specific pathogen encountered, and are able to mount a strong and rapid response if the same pathogen is detected again; this is known as acquired immunity.
Natural killer cells
NK cells are a part of the innate immune system and play a major role in defending the host from tumors and virally infected cells. Its existence as a cell type has been challenged by two studies. However, the authors of original article pointed to the fact that the two studies have detected X cells by imaging microscopy and FACS as described. Additional studies are required to determine the nature and properties of X cells (also called dual expressers).
Development
thumb|300px|[[haematopoiesis|Development of blood cells|left]]
Mammalian stem cells differentiate into several kinds of blood cell within the bone marrow. This process is called haematopoiesis<!--(hematopoiesis = U.S. spelling)-->. All lymphocytes originate, during this process, from a common lymphoid progenitor before differentiating into their distinct lymphocyte types. The differentiation of lymphocytes follows various pathways in a hierarchical fashion as well as in a more plastic fashion. The formation of lymphocytes is known as lymphopoiesis. In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricius, a lymphoid organ where they were first discovered by Chang and Glick,
!Class
!Function
!Proportion (median, 95% CI)
!Phenotypic marker(s)
|-
!Natural killer cells
|Lysis of virally infected cells and tumour cells
|7% (2–13%)
|CD16 CD56 but not CD3
|-
!T helper cells
|Release cytokines and growth factors that regulate other immune cells
|46% (28–59%)
|TCRαβ, CD3 and CD4
|-
!Cytotoxic T cells
|Lysis of virally infected cells, tumour cells and allografts
|19% (13–32%)
|TCRαβ, CD3 and CD8
|-
!Gamma delta T cells
|Immunoregulation and cytotoxicity
|5% (2–8%)
|TCRγδ and CD3
|-
!B cells
|Secretion of antibodies
|23% (18–47%)
|MHC class II, CD19 and CD20
|}
In the circulatory system, they move from lymph node to lymph node. This contrasts with macrophages, which are rather stationary in the nodes.
Lymphocytes and disease
thumb|Several lymphocytes seen collected around a tuberculous [[granuloma]]
A lymphocyte count is usually part of a peripheral complete blood cell count and is expressed as the percentage of lymphocytes to the total number of white blood cells counted.
A general increase in the number of lymphocytes is known as lymphocytosis, whereas a decrease is known as lymphocytopenia.
High
An increase in lymphocyte concentration is usually a sign of a viral infection (in some rare cases, leukemias are found through an abnormally raised lymphocyte count in an otherwise normal person). A high lymphocyte count with a low neutrophil count might be caused by lymphoma. Pertussis toxin (PTx) of Bordetella pertussis, formerly known as lymphocytosis-promoting factor, causes a decrease in the entry of lymphocytes into lymph nodes, which can lead to a condition known as lymphocytosis, with a complete lymphocyte count of over 4000 per μl in adults or over 8000 per μl in children. This is unique in that many bacterial infections illustrate neutrophil-predominance instead.
Lymphoproliferative disorders
Lymphoproliferative disorders (LPD) encompass a diverse group of diseases marked by uncontrolled lymphocyte production, leading to issues like lymphocytosis, lymphadenopathy, and bone marrow infiltration. These disorders are common in immunocompromised individuals and involve abnormal proliferation of T and B cells, often resulting in immunodeficiency and immune system dysfunction. Various gene mutations, both iatrogenic and acquired, are implicated in LPD. One subtype, X-linked LPD, is linked to mutations in the X chromosome, predisposing individuals to natural killer cell LPD and T-cell LPD. Additionally, conditions like common variable immunodeficiency (CVID), severe combined immunodeficiency (SCID), and certain viral infections elevate the risk of LPD. Treatment methods, such as immunosuppressive drugs and tissue transplantation, can also increase susceptibility. LPDs encompass a wide array of disorders involving B-cell (e.g., chronic lymphocytic leukemia) and T-cell (e.g., Sezary syndrome) abnormalities, each presenting distinct challenges in diagnosis and management.
Low
A low normal to low absolute lymphocyte concentration is associated with increased rates of infection after surgery or trauma.
One basis for low T cell lymphocytes occurs when the human immunodeficiency virus (HIV) infects and destroys T cells (specifically, the CD4<sup>+</sup> subgroup of T lymphocytes, which become helper T cells). Without the key defense that these T cells provide, the body becomes susceptible to opportunistic infections that otherwise would not affect healthy people. The extent of HIV progression is typically determined by measuring the percentage of CD4<sup>+</sup> T cells in the patient's blood – HIV ultimately progresses to acquired immune deficiency syndrome (AIDS). The effects of other viruses or lymphocyte disorders can also often be estimated by counting the numbers of lymphocytes present in the blood.
Tumor-infiltrating lymphocytes
In some cancers, such as melanoma and colorectal cancer, lymphocytes can migrate into and attack the tumor. This can sometimes lead to regression of the primary tumor.
Lymphocyte-variant hypereosinophilia
Blood content
thumb|800px|center|[[Reference ranges for blood tests of white blood cells, comparing lymphocyte amount (shown in light blue) with other cells]]
History
See also
- Addressin
- Anergy
- Complete blood count
- Cytotoxicity
- Human leukocyte antigen
- Lymphocystivirus
- Lymphoproliferative disorders
- Myeloid tissue
- Reactive lymphocyte
- Secretion assay
- Trogocytosis