Lukyanenko, often spelled Lukianenko, is a Ukrainian-language surname. It is a patronymic surname derived from the given name Lukian.
{| class="wikitable"
! Language !! Name
|-
| Belarusian <br>(Romanization) || <br>(Lukjanienka, Lukyanienka)
|-
| Russian <br>(Romanization) || <br> (Lukyanenko, Lukianenko, Lukjanenko)
|-
| Ukrainian <br>(Romanization) || <br> (Lukyanenko, Lukianenko, Lukjanenko)
|}
Notable people with the surname include:
- Artem Lukyanenko (born 1990), Russian decathlete
- Daria Lukianenko, (born 2002), Russian Paralympic swimmer
- Iryna Lukianenko, (born 1983), Ukrainian figure skating coach and former competitor
- Larisa Lukyanenko (born 1973), Belarusian individual rhythmic gymnast
- Levko Lukianenko (1928–2018), Ukrainian politician and Soviet dissident
- Sergei Lukyanenko (born 1968), Russian science fiction and fantasy author
- Vitaliy Lukyanenko (born 1978), Ukrainian biathlete
- Yevgeniy Lukyanenko (born 1985), Russian pole vaulter