Louis or Lou Johnson may refer to:
Government and politics
- Louis Johnson (politician) (born 1937), American politician
- Louis A. Johnson (1891–1966), second United States Secretary of Defense
- Louis Stanley Johnson (1869–1937), English politician
Sports
- Lou Johnson (1932–2020), American baseball player
- Lou Johnson (pitcher) (1869–1941), baseball player
- Louis "Dicta" Johnson (1887–?), American baseball pitcher
- Louis Johnson (boxer) (born 1938), American Olympic boxer
Others
- Louis Johnson (poet) (1924–1988), New Zealand poet
- Lou Johnson (singer) (1941–2019), American soul singer
- Louis Johnson (bassist) (1955–2015), American electric bassist
- Louis Johnson (dancer) (1930-2020), American dancer and choreographer
See also
- Llew Johnson, New Zealand cricketer
- Lewis Johnson (disambiguation)