Lofa may refer to:
- Lofa County, a county in Liberia
- Lofa Defense Force or LDF, a rebel group that participated in the Liberian Civil War
- Lofa River, a river in Liberia
- Lofa Tatupu (Mosiula Mea'alofa "Lofa" Tatupu, born 1982), American football linebacker
- Lofa-Mano National Park, a proposed national park in Liberia
- Leap of Faith Assumption, a concept of the Lean startup business development process
See also
- Lofanga, an island in Tonga