thumb|Loddon Valley Highway in [[Serpentine, Victoria|Serpentine]]
Loddon Valley Highway runs roughly north-west from Bendigo to Kerang. through the Parliament of Victoria provided for the establishment of the Country Roads Board (later VicRoads) and their ability to declare Main Roads, taking responsibility for the management, construction and care of the state's major roads from local municipalities. Bendigo-Serpentine Road was declared a Main Road from Bendigo to Yarraberb on 20 September 1915,
The passing of the Highways and Vehicles Act 1924 provided for the declaration of State Highways, roads two-thirds financed by the State government through the Country Roads Board. Loddon Valley Highway was declared a State Highway in 1946, granted the responsibility of overall management and development of Victoria's major arterial roads to VicRoads: in 2004, VicRoads re-declared the road as Loddon Valley Highway (Arterial #6630), beginning at Murray Valley Highway at Kerang and ending at Calder Highway in Ironbark, Bendigo.