{|class="wikitable sortable"
|-
! Senator !! Lifespan !! Party !! Prov. !! Entered !! Left !! Appointed by !! Left due to !! For life?
|-
| Raymonde Saint-Germain || 1951–present|| NA || QC || 25 November 2016 || — || Trudeau, J. || — ||
|-
| John Sewell Sanborn || 1819–1877 || L || QC || 23 October 1867 || 1 October 1872 || Royal proclamation || Resignation || Y
|-
| William Eli Sanford || 1838–1899 || C || ON || 8 February 1887 || 10 July 1899 || Macdonald || Death || Y
|-
| Arthur Sauvé || 1874–1944 || C || QC || 20 July 1935 || 6 February 1944 || Bennett || Death || Y
|-
| Calixte Savoie || 1895–1985 || IL || NB || 28 July 1955 || 23 August 1970 || St. Laurent || Voluntary retirement || Y
|-
| Frederick Laurence Schaffner || 1855–1935 || C || MB || 23 October 1917 || 22 May 1935 || Borden || Death || Y
|-
| John Christian Schultz || 1840–1896 || LC || MB || 23 September 1882 || 1 July 1888 || Macdonald || Resignation || Y
|-
| Richard William Scott || 1825–1913 || L || ON || 13 March 1874 || 23 April 1913 || Mackenzie || Death || Y
|-
| Hugh Segal || 1950–2023 || C || ON || 2 August 2005 || 15 June 2014 || Martin || Resignation ||
|-
| Judith Seidman || 1950–present|| C || QC || 27 August 2009 || — || Harper || — ||
|-
| Louis-Adélard Senécal || 1829–1887 || C || QC || 25 January 1887 || 11 October 1887 || Macdonald || Death || Y
|-
| Paulette Senior || 1961/1962–present || || ON || 20 December 2023 || — || Trudeau, J. || — ||
|-
| Asha Seth || 1939–present|| C || ON || 6 January 2012 || 15 December 2014 || Harper || Retirement ||
|-
| Raymond Setlakwe || 1928–2021 || L || QC || 20 June 2000 || 3 July 2003 || Chrétien || Retirement ||
|-
| Benjamin Seymour || 1806–1880 || C || ON || 23 October 1867 || 23 March 1880 || Royal proclamation || Death || Y
|-
| William Henry Sharpe || 1868–1942 || C || MB || 10 February 1916 || 19 April 1942 || Borden || Death || Y
|-
| Lytton Shatford || 1873–1920 || C || BC || 26 June 1917 || 8 November 1920 || Borden || Death || Y
|-
| James Shaw || 1797–1878 || C || ON || 23 October 1867 || 6 February 1878 || Royal proclamation || Death || Y
|-
| Joseph Shehyn || 1829–1918 || L || QC || 5 February 1900 || 14 July 1918 || Laurier || Death || Y
|-
| Cyril Sherwood || 1915–1996 || PC || NB || 3 October 1979 || 1 July 1990 || Clark || Retirement ||
|-
| Ian Shugart || 1957–2023 || || ON || 27 September 2022 || 25 October 2023 || Trudeau, J. || Death ||
|-
| Nick Sibbeston || 1943–present|| L→NA || NT || 2 September 1999 || 21 November 2017 || Chrétien || Retirement ||
|-
| Jean-Maurice Simard || 1931–2001 || PC || NB || 26 June 1985 || 16 June 2001 || Mulroney || Death||
|-
| Paula Simons || 1964–present|| || AB || 3 October 2018 || — || Trudeau, J. || — ||
|-
| John Simpson || 1812–1885 || L || ON || 23 October 1867 || 21 March 1885 || Royal proclamation || Death || Y
|-
| Ian David Sinclair || 1913–2006 || L || ON || 23 December 1983 || 27 September 1988 || Trudeau, P. || Retirement ||
|-
| John Ewen Sinclair || 1879–1949 || L || PE || 7 June 1930 || 23 December 1949 || King || Death || Y
|-
| Murray Sinclair || 1951–present|| NA || MB || 2 April 2016 || 31 January 2021 || Trudeau, J. || Resignation ||
|-
| rowspan="2" | James Skead || rowspan="2" | 1817–1884 || rowspan="2" | C || rowspan="2" | ON || 23 October 1867 || 20 January 1881 || Royal proclamation || Resignation || rowspan="2" | Y
|-
|24 December 1881
|5 July 1884
|Macdonald
|Death
|-
| Benjamin Franklin Smith || 1865–1944 || C || NB || 14 August 1935 || 19 May 1944 || Bennett || Death || Y
|-
| David Smith || 1941–2020 || L || ON || 25 June 2002 || 16 May 2016 || Chrétien || Retirement ||
|-
| Donald Smith || 1905–1985 || L || NS || 28 July 1955 || 7 July 1980 || St. Laurent || Voluntary retirement || Y
|-
| E. D. Smith || 1853–1948 || C || ON || 26 May 1913 || 10 January 1946 || Borden || Resignation || Y
|-
| Frank Smith || 1822–1901 || C || ON || 2 February 1871 || 1 January 1900 || Macdonald || Resignation || Y
|-
| rowspan="2" | Larry Smith || rowspan="2" | 1951–present|| rowspan="2" | C || rowspan="2" | QC || 18 December 2010 || 25 March 2011 || rowspan="2" | Harper || Resignation || rowspan="2" |
|-
|25 May 2011
|—
|—
|-
| George Isaac Smith || 1909–1982 || PC || NS || 7 August 1975 || 19 December 1982 || Trudeau, P. || Death||
|-
| Sydney John Smith || 1892–1976 || L || BC || 3 January 1957 || 31 December 1968 || St. Laurent || Resignation || Y
|-
| Jabez Bunting Snowball || 1837–1907 || L || NB || 1 May 1891 || 1 February 1902 || Macdonald || Resignation || Y
|-
| Karen Sorensen || 1959–present|| || AB || 29 July 2021 || — || Trudeau, J. || — ||
|-
| Herbert O. Sparrow || 1930–2012 || L || SK || 9 February 1968 || 4 January 2005 || Pearson || Retirement ||
|-
| James Houston Spence || 1867–1939 || L || ON || 10 January 1928 || 21 February 1939 || King || Death || Y
|-
| Mira Spivak || 1934–present|| C || MB || 17 November 1986 || 12 July 2009|| Mulroney || Retirement ||
|-
| Thomas Simpson Sproule || 1843–1917 || C || ON || 3 December 1915 || 10 November 1917 || Borden || Death || Y
|-
| Raymond Squires || 1926–2019 || L || NL || 9 June 2000 || 6 February 2001 || Chrétien || Retirement ||
|-
| Gerry St. Germain || 1937–present|| C || BC || 23 June 1993 || 6 November 2012 || Mulroney || Retirement ||
|-
| Édouard-Charles St-Père || 1876–1950 || L || QC || 9 February 1940 || 31 January 1950 || King || Death || Y
|-
| Wesley Stambaugh || 1888–1970 || L || AB || 7 September 1949 || 8 June 1965 || St. Laurent || Voluntary retirement || Y
|-
| Richard Stanbury || 1923–2014 || L || ON || 13 February 1968 || 2 May 1998 || Pearson || Retirement ||
|-
| John Stanfield || 1868–1934 || C || NS || 17 February 1921 || 22 January 1934 || Meighen || Death || Y
|-
| William Steeves || 1814–1873 || L || NB || 23 October 1867 || 9 December 1873 || Royal proclamation || Death || Y
|-
| David Steuart || 1916–2010 || L || SK || 9 December 1976 || 26 January 1991 || Trudeau, P. || Retirement ||
|-
| Gardner Green Stevens || 1814–1892 || L || QC || 12 February 1876 || 15 April 1892 || Mackenzie || Death || Y
|-
| John Stevenson || 1873–1956 || L || SK || 29 January 1940 || 21 September 1956 || King || Death || Y
|-
| John Benjamin Stewart || 1924–2015 || L || NS || 13 January 1984 || 19 November 1999 || Trudeau, P. || Retirement ||
|-
| Carolyn Stewart-Olsen || 1946–present|| C || NB || 27 August 2009 || 27 July 2021 || Harper || Retirement ||
|-
| Peter Stollery || 1935–present|| L || ON || 2 July 1981 || 29 November 2010 || Trudeau, P. || Retirement ||
|-
| Terry Stratton || 1938–present|| C || MB || 25 March 1993 || 16 March 2013 || Mulroney || Retirement ||
|-
| Joseph Albert Sullivan || 1902–1988 || PC || ON || 12 October 1957 || 18 February 1985 || Diefenbaker || Resignation || Y
|-
| Michael Sullivan || 1838–1915 || C || ON || 29 January 1885 || 29 November 1912 || Macdonald || Resignation || Y
|-
| Allister Surette || 1961–present || || NS || 19 December 2024 || — || Trudeau, J. || — ||
|-
| Donald Sutherland || 1863–1949 || C || ON || 20 July 1935 || 1 January 1949 || Bennett || Death || Y
|-
| John Sutherland || 1821–1899 || IC || MB || 13 December 1871 || 13 April 1899 || Macdonald || Resignation || Y
|-
| John Sylvain || 1924–2011 || PC || QC || 7 September 1990 || 1 February 1996 || Mulroney || Resignation||
|}