thumb|[[Soyuz TM-24 and Progress M-32 docked to the fore and aft ports Mir, as seen from the departing in September 1996 during STS-79.]]
Human spaceflights were vital to the operation of Mir, allowing crews and equipment to be carried to and from the space station. Mir was visited by a total of 39 crewed missions, comprising 30 Soyuz flights (1 Soyuz-T, 29 Soyuz-TM) and 9 Space Shuttle flights. These missions carried both long-duration crew members flying principal expeditions (ranging from 70 days up to Valeri Polyakov's 14-month stay beginning in January 1994, which still holds the record for the longest continuous spaceflight by a single person) and short-term visitors (who spent about a week aboard the station). Many of the crew who visited Mir used different spacecraft to launch than they did to land; the first such examples were Aleksandr Viktorenko and Muhammed Faris who flew up in Soyuz TM-3 (launched 22 July 1987) and landed a week later in Soyuz TM-2 on 30 July 1987. The largest crew aboard Mir simultaneously (not including Shuttle-Mir missions) was 6, which first occurred with the launch of Soyuz TM-7 on 26 November 1988 and lasted for just over three weeks.
In this list, uncrewed visiting spacecraft are excluded (see List of uncrewed spaceflights to Mir for details), and long-duration crew members are listed in bold. Times are given in Coordinated Universal Time (UTC). "Time docked" refers to the spacecraft and does not necessarily correspond to the crew.
{| id="toc" class="toc" summary="Class"
!
|-
| style="text-align:center;"|198619871988198919901991199219931994199519961997199819992000
|}
{|class="wikitable sticky-header" style="font-size: 85%;"
|-
! scope="col" |#
! scope="col" |Mission
! scope="col" |Launch date (UTC)
! scope="col" |Time docked
! scope="col" |Landing date (UTC)
! scope="col" |Launch crew
! scope="col" |Crew photo
! scope="col" |Crew patch
! scope="col" |Notes
|-
! scope="row" |1.
|align="center"|Soyuz T-15
|13 March 1986<br>12:33:09
|~52 days<br>~20 days
|16 July 1986<br>12:34:05
| Leonid Kizim<br>
Vladimir Solovyov
|
|100px
|Delivered the first crew, flying expedition EO-1, to Mir, then undocked, flew to and docked with Salyut 7 before returning to Mir. Remains the only spacecraft to have visited two space stations during one mission.
|-
! scope="row" |2.
|align="center"|Soyuz TM-2
|5 February 1987<br>21:38:16
|~172 days
|30 July 1987<br>01:04:12
| Yuri Romanenko<br>
Aleksandr Laveykin
|
|100px
|Delivered the second crew, flying expedition EO-2, to Mir.