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As of January 2025, Singapore Airlines (and its subsidiary Scoot) flies to 120 international destinations in 46 countries from its primary hub in Singapore Changi Airport. China is connected to sixteen airports, the highest number of destinations, India with 8 destinations, seven to Australia and six destinations in the US.
In 1992, Singapore Airlines discontinued flying to Madrid.
After the Asian Financial Crisis in 1997, Singapore Airlines discontinued flying to Berlin, Darwin, Cairns, Hangzhou, Kagoshima, and Sendai. Toronto was discontinued in 1994. During the SARS outbreak in 2003/04, Singapore Airlines discontinued flying to Brussels, Las Vegas, Chicago, Hiroshima, Kaohsiung, Mauritius, Vienna, Madrid, Seattle, Shenzhen and Surabaya. In addition, Singapore Airlines discontinued flights to Vancouver and Amritsar in 2009, and São Paulo in 2016.
Singapore Airlines presently operates the longest and second longest flights in the world, non-stop to New York–JFK and Newark respectively, using the Airbus A350-900ULR.
Between 2000-2010s, the airline suspended services in Pakistan due to lack of safety in Pakistan.
Singapore to Newark was the world's longest flight from 2004-2013, and 2018-2021, when they started JFK to Singapore.
Previously, it operated to Newark with the Airbus A340-500 aircraft until they were phased out in 2013. Non-stop service to Los Angeles, also previously operated with the A340-500, also resumed in November 2018 with the new A350-900ULR.
In 2014, the airline announced they would end services in Cairo and Riyadh due to low demand.
In October 2016, Singapore Airlines restarted its nonstop service from Singapore to the US with the launch of its new Singapore-San Francisco route. The route flies A350-900 aircraft and includes Business, Premium Economy and Economy classes.
The former Capital Express Route linking Singapore and Wellington via Canberra was replaced in May 2018 with Singapore-Sydney-Canberra-Singapore and Singapore-Melbourne-Wellington-Melbourne-Singapore routes.
In September 2020, the carrier announced that it would suspend services to Canberra, Dusseldorf, Stockholm and Wellington due to a drop in demand arising from the COVID-19 pandemic.
In 2022, the airline reopened services to Surabaya, many years after it ended services to that destination during the 1997 Asian financial crisis.
List (excluding destinations served by Scoot)
{|class="sortable wikitable"
!Country
!City
!Airport
!Notes
!Refs
|-
| rowspan="9" |Australia||Adelaide||Adelaide Airport||align=center| ||align=center|
|-
|Brisbane||Brisbane Airport||align=center| ||align=center|
|-
|Canberra||Canberra Airport||||align=center|
|-
|Darwin||Darwin International Airport||align=center| ||align=center|
|-
|Melbourne||Melbourne Airport||align=center| ||align=center|
|-
|Austria||Vienna||Vienna International Airport||||align=center|
|-
|Bahrain||Manama||Bahrain International Airport||||align=center|
|-
|Bangladesh||Dhaka||Hazrat Shahjalal International Airport||align=center| ||align=center|
|-
|Belgium||Brussels||Brussels Airport||align=center| ||align=center|
|-
|Brunei||Bandar Seri Begawan||Brunei International Airport||align=center| ||align=center|
|-
|rowspan="2"|Canada||Toronto||Toronto Pearson International Airport||||align=center|
|-
|Vancouver||Vancouver International Airport||||align=center|
|-
|rowspan="11"|China||rowspan="2"|Beijing||Beijing Capital International Airport||align=center| ||align=center|
|-
|Chengdu Tianfu International Airport||align=center| ||align=center|
|-
|Chongqing||Chongqing Jiangbei International Airport||align=center| || align="center" |
|-
|Nanjing||Nanjing Lukou International Airport||||align=center|
|-
|Shanghai||Shanghai Pudong International Airport||align=center| ||align=center|
|-
|rowspan="2"|France||rowspan="2"|Paris||Charles de Gaulle Airport||align=center| ||align=center|
|-
|rowspan="4"|Germany||Berlin||Berlin Schönefeld Airport||||align=center|
|-
|Düsseldorf||Düsseldorf Airport||||align=center|
|-
|Greece||Athens||Athens International Airport||||align=center|
|-
|rowspan="2"|Hong Kong||rowspan="2"|Hong Kong||Hong Kong International Airport||align=center| ||align=center|
|-
|Amritsar||Sri Guru Ram Dass Jee International Airport||||align=center|
|-
|Bengaluru||Kempegowda International Airport||align=center| ||align=center|
|-
|Iran||Tehran||Mehrabad International Airport||||align=center|
|-
|rowspan="8"|Japan||Fukuoka||Fukuoka Airport||align=center| ||align=center|
|-
|Sendai||Sendai Airport||||align=center|
|-
|Narita International Airport||align=center| ||align=center|
|-
|Macau<span id="Macau"></span>||Macau||Macau International Airport||||align=center|
|-
|Kuala Lumpur||Kuala Lumpur International Airport||align=center| ||align=center|
|-
|Kuching||Kuching International Airport||||align=center|
|-
|Mauritius||Port Louis||Sir Seewoosagur Ramgoolam International Airport||||align=center|
|-
|Nepal||Kathmandu||Tribhuvan International Airport||align=center| ||align=center|
|-
|rowspan="3"|Philippines||Cebu||Mactan–Cebu International Airport||align=center| ||align=center|
|-
|Davao||Francisco Bangoy International Airport||||align=center|
|-
|Manila||Ninoy Aquino International Airport||align=center| ||align=center|
|-
|rowspan="3"|Saudi Arabia||Dhahran||Dhahran International Airport||||align=center|
|-
|Jeddah||King Abdulaziz International Airport||||align=center|
|-
|rowspan="2"|Singapore||rowspan="2"|Singapore||Changi Airport||||align=center|
|-
|rowspan="3"|South Africa||Cape Town||Cape Town International Airport||align=center| ||align=center|
|-
|Seoul||Incheon International Airport||align=center| ||align=center|
|-
|Sri Lanka||Colombo||Bandaranaike International Airport||align=center| ||align=center|
|-
|Atatürk Airport||||align=center|
|-
|Heathrow Airport||align=center| ||align=center|
|-
|Houston||George Bush Intercontinental Airport||||align=center|
|-
|Los Angeles||Los Angeles International Airport||align=center| ||align=center|
|-
|San Francisco||San Francisco International Airport||align=center| ||align=center|
|-
|rowspan="3"|Vietnam||Da Nang||Da Nang International Airport||align=center| ||align=center|
|-
|Hanoi||Noi Bai International Airport||align=center| ||align=center|