This is an alphabetical list of baseball players from Panama who played in Major League Baseball between and . The first Panamanian ever to appear in the Majors was Humberto Robinson.
Current
In order of MLB debut (oldest - newest)
- Edmundo Sosa for the Philadelphia Phillies
- Justin Lawrence for the Pittsburgh Pirates
- Ivan Herrera for the St. Louis Cardinals
- José Caballero for the New York Yankees
- Miguel Amaya for the Chicago Cubs
Current
Minor League Baseball
- Jonathan Arauz
- Johan Camargo
- Allen Córdoba
- Randall Delgado
- José Ramos
- Paolo Espino
- Ariel Jurado
- Rubén Tejada
- Darío Agrazal
- Adan Sanchez
Former
- Ed Acosta
- Manny Acosta
- Jonathan Arauz
- Jaime Barria
- Manuel Barrios
- Juan Berenguer
- Christian Bethancourt
- Enrique Burgos (born 1965)
- Enrique Burgos (born 1990)
- Rod Carew
- Ossie Chavarria
- Ángel Chávez
- Bruce Chen
- Webbo Clarke
- Manny Corpas
- Roger Deago
- Luis Durango
- Einar Díaz
- Mike Eden
- Gil Garrido
- Severino González
- Javy Guerra
- Bill Haywood
- Tom Hughes
- Roberto Kelly
- Carlos Lee
- Allan Lewis
- Héctor López
- José Macías
- Carlos Maldonado
- Rafael Medina
- Ramiro Mendoza
- Orlando Miller
- Omar Moreno
- Julio Mosquera
- Ivan Murrell
- Sherman Obando
- Ben Oglivie
- Adolfo Phillips
- Bobby Prescott
- Fernando Ramsey
- Mariano Rivera
- Rubén Rivera
- Dave Roberts
- Humberto Robinson
- Davis Romero
- Carlos Ruiz
- Olmedo Sáenz
- Chico Salmon
- Manny Sanguillén
- Pat Scantlebury
- Fernando Seguignol
- Rennie Stennett
- Ray Webster
- Julio Zuleta