Aeroméxico and Aeroméxico Connect, which are both commercialized as Aeroméxico, serve the following destinations, .
Aeroméxico destinations
{|class="sortable wikitable"
|-
!Country
!City
!Airport
!Notes
!class="unsortable"|Refs
|-
|Argentina||Buenos Aires||Ministro Pistarini International Airport||align=center| ||align=center|
|-
|rowspan="2"|Brazil||Rio de Janeiro||Rio de Janeiro/Galeão International Airport||||align=center|
|-
|São Paulo||São Paulo/Guarulhos International Airport||align=center| ||align=center|
|-
|Montreal||Montréal–Trudeau International Airport||align=center| ||align=center|
|-
|Vancouver||Vancouver International Airport||align=center| ||align=center|
|-
|Chile||Santiago||Arturo Merino Benítez International Airport||||align=center|
|-
|China||Shanghai||Shanghai Pudong International Airport||||align=center|
|-
|rowspan="4"|Colombia||Bogotá||El Dorado International Airport||align=center| ||align=center|
|-
|Medellín||José María Córdova International Airport||align=center| ||align=center|
|-
|Costa Rica||San José||Juan Santamaría International Airport||align=center| ||align=center|
|-
|rowspan="2"|Dominican Republic||Punta Cana||Punta Cana International Airport||||align=center|
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|Santo Domingo||Las Américas International Airport||align=center| ||align=center|
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|rowspan="2"|Ecuador||Quito||Mariscal Sucre International Airport|| ||align=center|
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|Guayaquil||José Joaquín de Olmedo International Airport||||align=center|
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|El Salvador||San Salvador||El Salvador International Airport||align=center| ||align=center|
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|Orly Airport||||align=center|
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|Japan||Tokyo||Narita International Airport|| ||align=center|
|-
|rowspan="28"|Mexico||Acapulco||Acapulco International Airport||align=center| ||align=center|
|-
|Aguascalientes||Aguascalientes International Airport||align=center| ||align=center|
|-
|Cancún||Cancún International Airport||align=center| ||align=center|
|-
|Chihuahua||Chihuahua International Airport||align=center| ||align=center|
|-
|||Ciudad del Carmen International Airport||align=center| ||align=center|
|-
|Ciudad Juárez||Ciudad Juárez International Airport||align=center| ||align=center|
|-
|Cozumel||Cozumel International Airport||||align=center|
|-
|Culiacán||Culiacán International Airport||align=center| ||align=center|
|-
|Guadalajara||Guadalajara International Airport||||align=center|
|-
|Hermosillo||Hermosillo International Airport||align=center| ||align=center|
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|Huatulco||Bahías de Huatulco International Airport||align=center| ||align=center|
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|León||Bajío International Airport||align=center| ||align=center|
|-
|Mazatlán||Mazatlán International Airport||align=center| ||align=center|
|-
|Mérida||Mérida International Airport||align=center| ||align=center|
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|Mexicali||Mexicali International Airport||align=center| ||align=center|
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|Mexico City||Mexico City International Airport||||align=center|
|-
|Tuxtla Gutiérrez||Tuxtla Gutiérrez International Airport||align=center| ||align=center|
|-
|Veracruz||Veracruz International Airport||align=center| ||align=center|
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|Villahermosa||Villahermosa International Airport||align=center| ||align=center|
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|Netherlands||Amsterdam||Amsterdam Airport Schiphol||align=center| ||align=center|
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|rowspan="2"|Spain||Barcelona||Josep Tarradellas Barcelona–El Prat Airport|| ||align=center|
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|Madrid||Madrid–Barajas Airport||align=center| ||align=center|
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|United Kingdom||London||Heathrow Airport||align=center| ||align=center|
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|rowspan="32"|United States||Albuquerque||Albuquerque International Sunport||||align=center|
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|Austin||Austin–Bergstrom International Airport||align=center| ||align=center|
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|Boston||Logan International Airport||align=center| ||align=center|
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|Brownsville||Brownsville/South Padre Island International Airport||||align=center|
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|Chicago||O'Hare International Airport||align=center| ||align=center|
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|Dallas||Dallas/Fort Worth International Airport||align=center| ||align=center|
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|Denver||Denver International Airport|| ||align=center|
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|Detroit||Detroit Metropolitan Airport|| ||align=center|
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|Fresno||Fresno Yosemite International Airport||align=center| ||align=center|
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|Houston||George Bush Intercontinental Airport||align=center| ||align=center|
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|Laredo||Laredo International Airport||||align=center|
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|New Orleans||Louis Armstrong New Orleans International Airport||||align=center|
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|New York City||John F. Kennedy International Airport||align=center| ||align=center|
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|Orlando||Orlando International Airport||align=center| ||align=center|
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|Philadelphia||Philadelphia International Airport || ||align=center|
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|Phoenix||Phoenix Sky Harbor International Airport || ||align=center|
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|Portland|||Portland International Airport||||align=center|
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|Sacramento||Sacramento International Airport||align=center| ||align=center|
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|Salt Lake City||Salt Lake City International Airport|| ||align=center|
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|San Antonio||San Antonio International Airport|| ||align=center|
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|San Francisco||San Francisco International Airport||align=center| ||align=center|
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|San Jose||San Jose International Airport||||align=center|
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|Tucson||Tucson International Airport||||align=center|
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|Washington, D.C.||Dulles International Airport||||align=center|
|}
Aeroméxico Connect destinations
Aeroméxico Connect serves the following destinations (as of May 2026):
|-
|Colombia||Medellín||José María Córdova International Airport||||align=center|
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|Costa Rica||Liberia||Guanacaste Airport||||align=center|
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|Cuba||Havana||José Martí International Airport|| ||align=center|
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|rowspan="53"|Mexico||Acapulco||Acapulco International Airport||align=center| ||align=center|
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|Aguascalientes||Aguascalientes International Airport||align=center| ||align=center|
|-
|Campeche||Campeche International Airport||align=center| ||align=center|
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|Cancún||Cancún International Airport||align=center| ||align=center|
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|Chetumal||Chetumal International Airport|| ||align=center|
|-
|Chihuahua||Chihuahua International Airport||align=center| ||align=center|
|-
|Ciudad Juárez||Ciudad Juárez International Airport||align=center| ||align=center|
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|||Ciudad del Carmen International Airport||align=center| ||align=center|
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|Ciudad Obregón||Ciudad Obregón International Airport||align=center| ||align=center|
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|Ciudad Victoria||Ciudad Victoria International Airport|| ||align=center|
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|Colima||Colima Airport|| ||align=center|
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|Culiacán||Culiacán International Airport||align=center| ||align=center|
|-
|Durango||Durango International Airport||align=center| ||align=center|
|-
|Guadalajara||||||align=center|
|-
|Hermosillo||Hermosillo International Airport||align=center| ||align=center|
|-
|Huatulco||Bahías de Huatulco International Airport||align=center| ||align=center|
|-
|Ixtapa||Ixtapa-Zihuatanejo International Airport||align=center| ||align=center|
|-
|La Paz||La Paz International Airport||align=center| ||align=center|
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|León/El Bajío||Bajío International Airport||align=center| ||align=center|
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|Los Mochis||Los Mochis International Airport||align=center| ||align=center|
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|Manzanillo||Playa de Oro International Airport||align=center| ||align=center|
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|Matamoros||Matamoros International Airport||align=center| ||align=center|
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|Mazatlán||Mazatlán International Airport||align=center| ||align=center|
|-
|Mérida||Mérida International Airport||align=center| ||align=center|
|-
|Mexicali||Mexicali International Airport||align=center| ||align=center|
|-
|rowspan="2"|Mexico City||Mexico City International Airport||||align=center|
|-
|Felipe Ángeles International Airport ||||align=center|
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|Minatitlán||Minatitlán International Airport||align=center| ||align=center|
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|Monterrey||Monterrey International Airport||||align=center|
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|Morelia||General Francisco Mujica International Airport|| ||align=center|
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|Nuevo Laredo||Nuevo Laredo International Airport||align=center| ||align=center|
|-
|Oaxaca||Oaxaca International Airport||align=center| ||align=center|
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|Poza Rica||El Tajín National Airport||||align=center|
|-
|Puebla||Puebla International Airport|| ||align=center|
|-
|||Puerto Escondido International Airport||align=center| ||align=center|
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|Puerto Vallarta||||align=center| ||align=center|
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|Querétaro||Querétaro Intercontinental Airport||align=center| ||align=center|
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|Reynosa||General Lucio Blanco International Airport||align=center| ||align=center|
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|Saltillo||Saltillo Airport|| ||align=center|
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|||Los Cabos International Airport||align=center| ||align=center|
|-
|San Luis Potosí||San Luis Potosí International Airport||align=center| ||align=center|
|-
|Tampico||Tampico International Airport||align=center| ||align=center|
|-
|Tapachula||Tapachula International Airport||align=center| ||align=center|
|-
|Tepic||Tepic International Airport|| ||align=center|
|-
|Tuxtla Gutiérrez||Tuxtla Gutiérrez International Airport||align=center| ||align=center|
|-
|Veracruz||Veracruz International Airport||align=center| ||align=center|
|-
|Villahermosa||Villahermosa International Airport||align=center| ||align=center|
|-
|Zacatecas||Zacatecas International Airport||align=center| ||align=center|
|-
|Nicaragua||Managua||Augusto C. Sandino International Airport||align=center| ||align=center|
|-
|Panama||Panama City||Tocumen International Airport|| ||align=center|
|-
|rowspan="16"|United States||Atlanta||Hartsfield–Jackson Atlanta International Airport||||align=center|
|-
|Austin||Austin–Bergstrom International Airport||align=center| ||align=center|
|-
|Chicago||O'Hare International Airport||||align=center|
|-
|Dallas||Dallas/Fort Worth International Airport||align=center| ||align=center|
|-
|Denver||Denver International Airport||||align=center|
|-
|Houston||George Bush Intercontinental Airport||align=center| ||align=center|
|-
|Las Vegas||Harry Reid International Airport|| ||align=center|
|-
|Los Angeles||Los Angeles International Airport||||align=center|
|-
|McAllen||McAllen Miller International Airport||||align=center|
|-
|Orlando||Orlando International Airport||||align=center|
|-
|Raleigh||Raleigh–Durham International Airport||||align=center|
|-
|Salt Lake City||Salt Lake City International Airport|| ||align=center|
|-
|San Antonio||San Antonio International Airport||align=center| ||align=center|
|-
|Tampa||Tampa International Airport||||align=center|
|-
|}