Lewis Run is a borough in McKean County, Pennsylvania, United States. The population was 583 at the 2020 census.
|footnote=Sources: U.S. Route 219 passes through the borough, leading north to Bradford, the largest community in the county, and south to Ridgway.
According to the U.S. Census Bureau, Lewis Run has a total area of , of which , or 0.60%, are water.