La Grande Soufrière (; ), or simply Soufrière (), is an active stratovolcano on the French island of Basse-Terre, Guadeloupe. It is the highest mountain peak in the Lesser Antilles, rising high.

The last magmatic eruption was in 1530±30 during which the current lava dome was emplaced.

More recent eruptions have been phreatic in type. On February 8, 1843, an eruption of La Grande Soufrière caused by an earthquake killed over 5,000 people.

Significant seismic activity in 1976 led to a mass evacuation of the island's 72,000 residents.