LCMS refers to the Lutheran Church – Missouri Synod, a conservative Lutheran body in the United States.
LCMS may also refer to:
Science and technology
- Liquid chromatography–mass spectrometry, a chemical analysis technique
- Learning content management system
- LittleCMS, an open-source color management system
Organizations
- Lindero Canyon Middle School, Agoura Hills, California, United States
- Los Cerritos Middle School, Thousand Oaks, California, United States
- Lutheran Church in Malaysia and Singapore