thumb|left|Along the Komoé River, 1892
The Komoé River or Comoé River is a river in West Africa. The river originates on the Sikasso Plateau of Burkina Faso, flows through the Cascades de Karfiguéla, forms a short section of the border between Burkina Faso and Ivory Coast before entering Ivory Coast. It serves as the major drainage for the northeastern portion of that country before emptying into the Atlantic. The banks of the Komoé are shaded by riparian forests along most of its length, providing an important habitat for wildlife and a source of agricultural water. Upstream of the Karifiguela Falls it is known locally as the Koba River.