The kilocalorie per mole is a unit to measure an amount of energy per number of molecules, atoms, or other similar particles. It is defined as one kilocalorie of energy (1000 thermochemical gram calories) per one mole of substance. The unit symbol is written kcal/mol or kcal⋅mol<sup>−1</sup>. As typically measured, one kcal/mol represents a temperature increase of one degree Celsius in one liter of water (with a mass of 1&nbsp;kg) resulting from the reaction of one mole of reagents.

In SI units, one kilocalorie per mole is equal to 4.184 kilojoules per mole (kJ/mol), which comes to approximately joules per molecule, or about 0.043&nbsp;eV per molecule. At room temperature (25&nbsp;°C, 77&nbsp;°F, or 298.15&nbsp;K), one kilocalorie per mole is approximately equal to 1.688 kT per molecule.

Even though it is not an SI unit, the kilocalorie per mole is still widely used in chemistry

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