Kazusa may refer to:
- , former province of Japan
- , former town in Minamitakaki District, Nagasaki Prefecture, Japan
People with the surname
- (died 1183), Japanese samurai lord and gōzoku
- , Japanese voice actress
People with the given name
- (born 1975), Japanese voice actress
- , Japanese Paralympic judoka
- , Japanese model
- , Japanese manga artist
Fictional characters
- Kazusa Kyoyama, a character in the role-playing video game Blue Archive
- Kazusa Onodera, a character in the manga O Maidens in Your Savage Season
- Kazusa Touma, a character in the visual novel White Album 2
- Kazusa Yamashiro, a character in the anime Muv-Luv Alternative: Total Eclipse