Kati Thanda-Lake Eyre National Park, formerly known as Lake Eyre National Park, is a protected area in the Australian state of South Australia. It is located 697 km north of the state capital of Adelaide within the gazetted locality of Lake Eyre. It contains both the north and south sections of Lake Eyre as well as sections of the Tirari Desert.
The national park protects dry desert landscapes, the nation's largest salt lake, Kati Thanda-Lake Eyre, and the lowest point on the mainland. As of 2012, the national park has been subject to a co-management agreement between the Arabana aboriginal people and the Department of Environment, Water and Natural Resources.
The national park was renamed as Kati Thanda-Lake Eyre National Park on 14 November 2013.
The national park is classified as an IUCN Category VI protected area.