KHK may refer to:
- Kappa Eta Kappa, an American professional fraternity
- Ketohexokinase, a fructose phosphorylase
- Katholieke Hogeschool Kempen, a former Belgian college
- Kanun Hükmünde Kararname, a form of decree-law in Turkey
- Kyowa Hakko Kirin, a former name for the pharmaceutical company Kyowa Kirin
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