Josef Maria Issels (November 21, 1907 – February 11, 1998) was a German physician known for promoting an alternative cancer treatment, the Issels treatment. He claimed to cure cancer patients who had been declared incurable by conventional cancer treatments. During Issels' lifetime, his methods were controversial, and in 1961 he was charged with fraud and manslaughter for allegedly promising fraudulent cancer cures and for the subsequent deaths of patients under his care who refused standard cancer treatment. Since at least 1972 the Issels treatment is described as unproven, and considered ineffective as a treatment for cancer.

Early life

Born in Mönchengladbach in 1907, Issels received his medical degree in 1932 from the University of Würzburg. According to an obituary in the Journal of Alternative and Complementary Medicine, Issels made a name for himself as a young physician several years later by successfully operating in makeshift conditions on an ill passenger aboard a German steamer.

A review of Issels' claims by the American Cancer Society concluded that there was no evidence that treatment with Issels Combination Therapy or any related treatments were effective against cancer.