John S. McCain may refer to:
People
- John S. McCain Sr. (1884–1945), United States Navy admiral
- John S. McCain Jr. (1911–1981), United States Navy admiral and son of John S. McCain Sr.
- John S. McCain III (1936–2018), United States Navy captain, American statesman, politician, and son of John S. McCain Jr.
Ships
- , a U.S. Navy ship name
- , a Mitscher-class destroyer in the United States Navy from 1953 to 1978
- , an Arleigh Burke-class destroyer in the United States Navy since 1994
See also
- John McCain (disambiguation)