John Isaac Guion (November 18, 1802 – June 6, 1855) was an American politician from Mississippi who served as acting Governor in 1851 following the resignation of Governor John A. Quitman.
thumb|Painting of Guion on display at the [[Old Warren County Courthouse]]
Biography
Guion was born in Adams County in Mississippi Territory to Sarah Lewis and U.S. Army officer and planter Isaac Guion. He studied law in Lebanon, Tennessee along with William L. Sharkey, was admitted to the bar, and established a successful practice in Vicksburg, Mississippi. He practiced in partnership with Sharkey and later with Seargent Smith Prentiss. was appointed circuit court judge in 1836, and was elected as a Democrat to the state senate for Warren County from 1842 to 1846.