Jerzy Radziwiłł (; 1480 – April 1541), nicknamed "Hercules", was a Lithuanian nobleman.
He was Deputy Cup-Bearer of Lithuania from 1510, voivode of Kiev from 1510, Field Lithuanian Hetman in 1521, castellan of Trakai from 1522, castellan of Vilnius from 1527, Marshal of the Court from 1528, Grand Lithuanian Hetman from 1531, Starost of Hrodna, Namiestnik of Vilnius, Maišiagala, Merkinė, Utena, Mozyrsk, Lida, Skidal, , Kryńsk and Oziersk. He was a progenitor of the Biržai–Dubingiai (also known as Protestant) Radziwiłł family line.
He was renowned for his military achievements and as a talented politician. He took part in various conflicts against Muscovy, the Cossacks and the Tatars. Achieving around 30 military victories, he has been referred as the Lithuanian Hercules.
In 1526 as a member of the Lithuanian Council of Lords he unsuccessfully petitioned the Grand Duke of Lithuania Sigismund I the Old for the renewal of a Kingdom of Lithuania under the rule of Sigismund the Old's son, Sigismund II Augustus.
- Mikołaj Radziwiłł the Red (1512–1584), who would later become Grand Lithuanian Hetman, married to Katarzyna Tomicka from Iwno h. Łodzia
- Anna Elżbieta Radziwiłł (1518–1558), married Symeon Holszański Dubrowicki h. Hipocentaur and marszałek of Volhynia Piotr Kiszka h. Dąbrowa (died 1550) in 1548
- Barbara Radziwiłł (1520–1551), married Stanislovas Goštautas and after his death in 1547 secretly married king of Poland Sigismund II Augustus and was crowned the queen consort the following year, despite protests by the Sejm and the Senate
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