thumb|left|150px|Coat arms of James Hepburn.
James Hepburn (died 1524) was a Scottish prelate and administrator. He was the son of Alexander Hepburn of Whitsome. His name occurs as the rector of Dalry and king's clerk on 1 August 1511. Hepburn was Treasurer of Scotland between from at least June 1515, until October the following year. He also held the position of rector of Parton in the diocese of Galloway.
Hepburn had been granted the temporalities of the see by 28 August. Although Archbishop Forman (d. 1521) had consented to this, his successor James Beaton resented it, and wrote to a senior Cardinal as a part of a wider attempt to have this reversed.