Jack of Spades may refer to:
- Jack of spades (playing card)
- Jack of Spades (1960 film), a French drama film directed by Yves Allégret
- Jack of Spades (upcoming film), an American Gothic mystery film directed by Joel Coen.
- Jack of Spades, a fictional character, a member of the villainous Royal Flush Gang in DC Comics
- Jack of Spades: A Tale of Suspense, a 2015 book by Joyce Carol Oates
- The Jack of Spades, a historical novella in Special Assignments: The Further Adventures of Erast Fandorin
See also
- Knave (disambiguation)
- Jack of Clubs (disambiguation)
- Jack of Diamonds (disambiguation)
- Jack of Hearts (disambiguation)
- Queen of Spades (disambiguation)
- King of Spades (disambiguation)
- Ace of Spades (disambiguation)