The Isle (; ) is a long river in south-western France, right tributary of the Dordogne. Its source is in the north-western Massif Central, near the town Nexon (south of Limoges). It flows south-west through the following départements and towns:
- Haute-Vienne: Le Chalard
- Dordogne: Périgueux, Mussidan
- Gironde: Libourne
It flows into the Dordogne in Libourne. Among the tributaries of the Isle are the Auvézère, the Loue, the Beauronne and the Dronne.