Isabella of Spain or Isabel of Spain may refer to:

  • Isabella I of Castile (1451–1504), queen regnant
  • Isabella II of Spain (1830–1904), queen regnant
  • Isabella of Austria (1501–1526), Spanish infanta, queen consort of Denmark-Norway
  • Isabella Clara Eugenia (1566–1633), Spanish infanta, archduchess of the Spanish Netherlands
  • María Isabella of Spain (1789–1848), Spanish infanta, queen consort of the Kingdom of the Two Sicilies
  • Infanta Isabel, Countess of Girgenti, Princess of Asturias (1851-1931), Spanish infanta

See also

  • Isabella, Princess of Asturias (disambiguation)
  • Isabella of Castile (disambiguation)