Interstate 76 (I-76) is an east–west Interstate Highway in the Eastern United States. The highway runs approximately from an interchange with I-71 west of Akron, Ohio, east to I-295 in Bellmawr, New Jersey. This route is not contiguous with I-76 in Colorado and Nebraska.
Starting in Ohio, the highway runs west of Akron to west of Youngstown, where it joins the Ohio Turnpike as a toll road. At the Pennsylvania state line, the Ohio Turnpike ends and becomes the Pennsylvania Turnpike, also a tolled facility. Along the turnpike, the route runs approximately across most of the southern portion of the state, serving the Pittsburgh and Harrisburg areas. At the Valley Forge Interchange, I-76 leaves the turnpike and turns southeast on the Schuylkill Expressway, where it parallels the Schuylkill River toward the city of Philadelphia. After entering Philadelphia, I-76 crosses the Delaware River on the Walt Whitman Bridge into New Jersey. After only about in New Jersey along the North–South Freeway, I-76 reaches its eastern terminus, though the freeway continues south as Route 42.