Interstate 59 (I-59) is an Interstate Highway located in the southeastern United States. It is a north–south route that spans from a junction with I-10 and I-12 at Slidell, Louisiana, to a junction with I-24 near Wildwood, Georgia.
The highway connects the metropolitan areas of New Orleans, Louisiana; Birmingham, Alabama; and Chattanooga, Tennessee, running closely parallel to the older U.S. Route 11 (US 11) corridor for the entire distance. Approximately one-third of the route, spanning from Meridian, Mississippi, to Birmingham, Alabama, overlaps that of the east–west I-20.
I-59 is a four-lane freeway along its entire route, other than a short stretch from Tuscaloosa, Alabama to the southern terminus of I-459 and in Birmingham, where it widens to six lanes or more. Aside from the metropolitan areas it passes through, the I-59 corridor is mainly rural in nature, especially in Georgia.