Illinois Route 351 is a north–south state route that leads from Illinois Route 71 and Illinois Route 251 by Oglesby through downtown LaSalle to Interstate 80. It is long. From 1963 to 1966, it became US 51 Business (US 51 Bus.) as US 51 was rerouted west of LaSalle along present-day Illinois Route 251. After 1966, it was then changed to IL 351.

Major intersections