Ichthyothere is a genus of flowering plants, found in parts of South America (the Amazon) and Central America.

The name ichthyothere literally translates as fish poison. These plants' active constituent is a chemical called ichthyothereol, which is a polyyne compound that is highly toxic to fish and mammals. Ichthyothere terminalis leaves have traditionally been used to make poisoned bait by indigenous peoples of the lower Amazon basin.

;Species

Species accepted by the Plants of the World Online as of December 2022:

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