Vishtaspa ( ; , ), hellenized as Hystáspes (, ), may refer to:
- Vishtaspa (fl. between 10th and 6th century BCE, if historical), the first patron of Zoroaster
- Hystaspes (father of Darius I) (fl. 550 BCE), satrap of Bactria and possibly also of Fārs, and father of Darius the Great
- Hystaspes (son of Darius I) (fl. 480 BCE), son of Darius the Great
- Hystaspes (son of Xerxes I) (fl. c. 460 BCE), son of Xerxes I of Persia
- Hystaspes, the older brother of the legendary king Zariadres of the North Caucasus