Hesychius () may refer to:
- Hesychius of Cazorla (first century), Spanish Christian missionary, bishop, martyr and saint
- Hesychius of Antioch (fourth century), Antioch saint
- Hesychius of Sinai (fourth century), Byzantine hieromonk and author
- Hesychius of Alexandria (probably fifth century), Alexandrian lexicographer
- (third–fourth century), Egyptian bishop and Christian martyr and saint to whom is attributed a recension of the Septuagint; said to be the same as , Alexandrian writer
- Hesychius of Jerusalem (probably fifth century), Jerusalem Christian presbyter and exegete
- Hesychius I (bishop of Vienne) (fifth century), French bishop and saint
- Hesychius II (bishop of Vienne) (sixth century), French bishop and saint
- Hesychius I (bishop of Grenoble) (sixth century), French bishop
- Hesychius of Miletus (sixth century), Greek chronicler and biographer