HRD may refer to:
Science and medicine
- Hertzsprung–Russell diagram, in astronomy
- Homologous recombination deficiency
- Hurricane Research Division, of the United States National Oceanic and Atmospheric Administration
Sport
- Home Run Derby, Major League Baseball
- Humboldt Roller Derby
- Houston Roller Derby
- Hurdles
Places
- Huanghe River Delta, China; the river delta of the Yellow River
- Harlem River Drive, New York City, New York State, USA
- Harden railway station (station code <code>HRD</code>), New South Wales, Australia
- Harling Road railway station (station code <code>HRD</code>), England, UK
- Harsud railway station (station code <code>HRD</code>), Madhya Pradesh, India
Other uses
- Croatian dinar (ISO currency code <code>HRD</code>), a former currency of Croatia
- Handel Reference Database
- Hood River Distillers
- HRD, a Rockwell scale of materials' hardness
- HRD Motorcycles, a British motorcycle manufacturer
- Human remains detection
- Human resource development
- Human rights defender