HLS may refer to:
Organisations
- Harlington Locomotive Society, London, England
- Huntingdon Life Sciences, a British contract research organisation
- HLS Ost (; ), German WWII cryptanalysis station
Education
- Harvard Law School, Cambridge, Massachusetts, US
- Helen Lowry Higher Secondary School, Mizoram, India
- Highlands Latin School, Louisville, Kentucky, US
Technology
- HTTP Live Streaming, a media streaming communications protocol
- HLS color space, a representation of points in an RGB color model
- High-level synthesis, an automated design process
Transportation
- Human Landing System, a NASA program to choose a Moon landing system for the 2020s
- Starship HLS, a modified version of the SpaceX Starship
- Heavy Logistics System, a USAF program to develop the Lockheed C-5 Galaxy
- Lockheed C-5 Galaxy, the winner of the USAF HLS project
- Haiti Air Freight (ICAO airline code <code>HLS</code>); see List of defunct airlines of Haiti
- Hilsea railway station (station code <code>HLS</code>), England, UK
Other uses
- Historical Dictionary of Switzerland (German: Historisches Lexikon der Schweiz)
- Holy See; also UNDP country code for Vatican City
- Himalayan Languages Symposium, an annual academic conference on Trans-Himalayan languages
See also
- Health and life sciences; see health sciences and life sciences
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- HL (disambiguation)
- HIS (disambiguation)