HFE may refer to:

Science and technology

  • HFE (gene), a gene that encodes the Human hemochromatosis protein
  • Hello from Earth, an interstellar radio message
  • Hidden Field Equations, a cryptosystem
  • H-parameter model (h<sub>FE</sub>), the current gain of a bipolar junction transistor
  • Human factors engineering
  • Hydrofluoroether, a solvent

Transport

  • Hefei Luogang International Airport, in Anhui, China, now defunct
  • Hefei Xinqiao International Airport, in Anhui, China
  • Hertford East railway station, in England

Other uses

  • Health First Europe
  • Herschend Family Entertainment Corporation, an American entertainment company
  • Horizontal Fiscal Equalisation, in Australia