HCM may refer to:
- Eyl Airport, in Puntland, Somalia
- Halifax Conservatory of Music, in Canada
- Hardware cryptographic module, a type of hardware security module (HSM)
- Harish Chandra Mathur, Indian politician, former chief minister of Rajasthan
- HCM Rajasthan State Institute of Public Administration, Jaipur, Rajasthan, India
- Harrow Central Mosque, in England
- Hausdorff Center for Mathematics, in Bonn, Germany
- Hierarchical Clustering Method (asteroids), a calculation to group asteroids into families
- Highway Capacity Manual, guide for highway standards etc. in the United States
- Historical-critical method, a branch of literary criticism
- Hitachi Construction Machinery, a Japanese company
- Ho Chi Minh, Prime Minister (1945–1955) and President (1945–1969) of North Vietnam
- Ho Chi Minh City, in Vietnam
- Human capital management, a subset of practices related to human resource management
- Hypertrophic cardiomyopathy, a disease of the myocardium (the muscle of the heart)