Guile or Guilé may refer to:
Fictional characters
- Guile (Street Fighter), a video game character from the Street Fighter series
- Guile, a video game character from Chrono Cross
People
- Daniel Guile (1814–1882), British trade unionist
- Melanie Guile (born 1949), Australian writer
Other uses
- Deception, and astuteness
- GNU Guile, an implementation of the Scheme programming language
- Guile Island, Antarctica
- Guilé Foundation, a Swiss organisation for business ethics
See also
- Guille (disambiguation)