Guadalupe River may refer to:
United States
- Guadalupe River (California), a tributary of the San Francisco Bay
- Guadalupe River (Texas), a tributary of the San Antonio Bay of the Gulf of Mexico
- Guadalupe River Park, a city park in San Jose, California
- Guadalupe River State Park, a Texas state park located along a section of the Guadalupe River in Kendall and Comal counties
- Rio Guadalupe (New Mexico), a tributary of the Jemez River
Other
- Guadalupe (Spain), a tributary of the Guadiana in southern Spain
See also
- Guadalope River, a tributary of the Ebro River in northern Spain