The Great Midwest Trivia Contest, or Midwest Trivia Contest, is held once a year in Appleton, Wisconsin, broadcast over Twitch. It has a claim as the longest-running college bowl trivia contest. It ends at around midnight on Sunday for a total of approximately 50 consecutive hours. Students are appointed "trivia masters" and they administer the contest. and teams are given 3 minutes to answer each question, The final, most difficult question – dubbed the "Super Garruda" – is worth 100 points and teams are given 30 minutes.

Questions used in the past include "What was Holden Caulfield's middle name?" and "In 2004, which nation drank the most coffee per capita?" (The answers are "Morrisey" and "Finland," respectively.) The 2009 Super Garruda was "Who was going to be married next to what was the "World's Largest Cedar Bucket" in Murfreesboro, Tennessee in June 2005, before it mysteriously burned down the week before the wedding date?" (answer: James Walters and Jaki Neubauer). In modern times, internet access has changed the way questions are written. Examples from the 2024 contest include "This primate was named after an anarchist critical of a linguist who shares a surname with the Simpsons character who said "steamed hams". What was the longest sentence the primate ever said?" and "This state house's original dome was metal-plated by the founding father who rides alongside the protagonist of Assassin's Creed III. What lies in its House of Representatives chamber, whose speaker pro tempore shares a last name with the ring name of the wrestler who had a cameo in Rocky III?" ("Give orange me give eat orange me eat orange give me eat orange give me you" and "Sacred Cod," respectively) On-campus teams are occasionally asked to do special action questions such as composing a love song or doing a dance routine based on a theme. deRosset visited his girlfriend at Beloit College; he was disappointed with Beloit's trivia contest and had ideas on how he wanted to improve on their contest. The first contest consisted of questions in four categories (television, rock 'n' roll music, comic books, and movies) that were written by deRosset and his friends. The radio station changed to internet broadcast and the first internet-only contest was held in 2006. The question difficulty had grown significantly because the teams could quickly find answers to simple questions using Google and the internet.

The 56th annual contest was held in 2021, and was held virtually instead of on WLFM radio as a response to the COVID-19 pandemic. The contest was streamed via Twitch.

The 58th annual contest was held in 2023 and saw the erection of the "Trivia Flag" on the cupola of Lawrence University's Main Hall, an ode to the year's theme: pirates.

The Lawrence trivia contest has been written about in Playboy, USA Today, The Chronicle of Higher Education, the Chicago Tribune, Washington Post,