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Gisgo or Gisco is the latinization or hellenization (, Géskōn) of the Punic masculine given name Gersakkun (, ). The name means "Client of Sakkun".
Notable people with the name Gisgo or Gisco include:
- Gisco, a son of Carthaginian general Hamilcar, exiled after the Battle of Himera in 480 BC
- Gisco (died 239 BC), a Carthaginian general who served during the closing years of the First Punic War and took a leading part in the events which sparked the Mercenary War
- Gisgo, son of Hanno the Great, who was a notable general of the Sicilian campaigns of the First Punic War
- Gisco, one of three ambassadors sent by Hannibal to King Philip V of Macedon in 215 BC