Giacomo Medici may refer to:
- Gian Giacomo Medici (c. 1495 - 1555), Italian condottiero
- (died 1594)
- Giacomo Medici (general) (1817-1882), Italian patriot and soldier
- Giacomo Medici Del Vascello (1883–1949), Italian Fascist politician and grandson of the former
- Giacomo Medici (art dealer), Italian illicit antiquities dealer