Gaius Antonius Hybrida (flourished 1st century BC) was a politician of the Roman Republic. He was the second son of Marcus Antonius and brother of Marcus Antonius Creticus; his mother is unknown. He was also the uncle of the famed triumvir Mark Antony. He had two children, Antonia Hybrida Major and Antonia Hybrida Minor.

Hybrida's career began under Lucius Cornelius Sulla, whom he accompanied into Greece as either a military tribune or a legatus. Later, in 63 BC, he was elected to serve as consul of the Roman Republic alongside Marcus Tullius Cicero. The two struck a deal which effectively allowed Cicero to rule as sole consul in exchange for Hybrida receiving the governorship of Macedonia at the end of his term. The same year, Hybrida was involved in suppressing the Catilinarian conspiracy, a plot to overthrow the state led by Lucius Sergius Catilina, or "Catiline", and which culminated in the Battle of Pistoria and the death of Catiline. After his consulship, Hybrida was granted Macedonia as had been promised. Here, Hybrida abused his rule to rob the provincials and led invasions of the neighbouring lands of Moesia. His incursions brought two separate attacks from the natives who successfully forced Hybrida out of their lands without any loot.

In 60 BC, Hybrida was quietly removed from the position of governor of Macedonia and replaced by Gaius Octavius. The next year, he was prosecuted by Julius Caesar and Marcus Licinius Crassus. The outcome of this was that Hybrida was forced to pay a fine and banished to the island Cephalonia. Sometime in 47, Hybrida was recalled from his banishment by Caesar. In 45, he made himself a candidate for the position of censor which ultimately failed. The final mention of Hybrida comes from Cicero in 44 when Mark Antony divorced himself from Hybrida's daughter Antonia Hybrida Minor.

Family

Hybrida was the younger of two sons of Marcus Antonius Orator; his brother was Marcus Antonius Creticus. He had also a sister, Antonia. He was also the uncle and father-in-law of Mark Antony. Hybrida had two daughters; Antonia Hybrida Major (major meaning "elder") who married the Roman tribune Lucius Caninius Gallus where he massacred all the Roman citizens he could find. He then sent troops to invade Greece, which in turn spurred some of the city-states to rebel against Rome. At the time Rome was embroiled in internal conflict through the Social War from 91 to 87.

Expulsion from, and return to, the Senate

Years later, in 70 BC, the censors Gellius and Lentulus expelled Hybrida from the Senate for the criminal offences committed by him while in Greece, for disobeying the summons of a praetor