Gainesville may refer to:
- Gainesville, Alabama
- Gainesville, Arkansas
- Gainesville, Florida
- Gainesville, Georgia
- Gainesville, Kentucky
- Gainesville, Mississippi
- Gainesville, Missouri
- Gainesville, New York
- Gainesville (village), New York, a village within the town of Gainesville
- Gainesville, Texas
- Gainesville, Virginia
See also
- Gainesville station