Gaines may refer to:
Places
;United States
- Gaines, Michigan, a village
- Gaines Township, Genesee County, Michigan, a civil township in which the above village is located
- Gaines Township, Kent County, Michigan, a charter township
- Gaines, New York, a town
- Gaines Township, Tioga County, Pennsylvania
- Gaines, West Virginia, an unincorporated community
People
- Gaines (surname)
- Gaines A. Knapp (1848–1918), American politician